Affiliations: [a] School of Mental Health, Wenzhou Medical University, Wenzhou, China
| [b] Dementia Care & Research Center, Beijing Dementia Key Lab, Peking University Institute of Mental Health (Sixth Hospital), Beijing, China
| [c] National Clinical Research Center for Mental Disorders, NHC Key Laboratory of Mental Health, Beijing, China
| [d] Hotchkiss Brain Institute and O’Brien Institute for Public Health, University of Calgary, Calgary, Canada
| [e] McGill Center for Studies in Aging; Douglas Mental Health Research Institute; McGill University, Montreal, Canada
Correspondence:
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Correspondence to: Prof. Xin Yu, School of Mental Health, Wenzhou Medical University, Chashan Higher Education Park, Ouhai District, Wenzhou 325035, China. E-mail: yuxin@bjmu.edu.cn. and Prof. Huali Wang, Dementia Care & Research Center, Peking University Institute of Mental Health, Beijing 100191, China.; E-mail: huali_wang@bjmu.edu.cn.
Abstract: Background:Mild behavioral impairment (MBI) has been proposed as an early manifestation of dementia. The Mild Behavioral Impairment Checklist (MBI-C) may help identify MBI in prodromal and preclinical dementia. Objective:The study aimed to evaluate the reliability and validity of the Chinese version of MBI-C in mild cognitive impairment (MCI) and mild Alzheimer’s disease (AD), and to explore the structure of the five factors of the MBI-C in Chinese culture. Methods:Sixty dyads of MCI and mild AD (MCI, n = 33; mild AD, n = 35) were recruited. The informants completed the MBI-C and Neuropsychiatric Inventory Questionnaire (NPI-Q) and were interviewed for clinician rating of the NPI. The Cronbach’s coefficient was used to measure the structural reliability of the MBI-C. The criterion-validity was evaluated with the correlation coefficient between the MBI-C and the total scores of NPI-Q and NPI. Exploratory factor analysis was conducted to investigate the structure of the MBI-C. Results:The Cronbach’s α coefficient was 0.895. The MBI-C total score was positively correlated with all five domains (r = 0.577∼0.840). The total score of MBI-C was significantly correlated with the total scores of NPI-Q (r = 0.714) and NPI (r = 0.749). Similarly, the five domain scores of MBI-C were significantly correlated with the factor and total scores of NPI-Q (r = 0.312∼0.673) and NPI (r = 0.389∼0.673). The components of each factor in Chinese version of MBI-C were slightly different from those of the a priori defined domains (χ2 = 1818.202, df = 496, p < 0.001). Conclusion:The Chinese version of MBI-C has good reliability and validity, and can be used to evaluate the psychological and behavioral changes in MCI and mild AD.
