Affiliations: [a] Robert Koch Institute, Berlin, Germany
| [b] Harvard University, Massachusetts General Hospital, Charlestown, MA, USA
| [c]
Viral Immunology, NINDS, NIH, Bethesda, MD, USA
Correspondence:
[*]
Correspondence to: Joachim Denner, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany. Tel.: +49
30187542800; E-mail: DennerJ@rki.de.
Abstract: Animal models to study Alzheimer’s disease (AD) pathogenesis are under development. Since herpesviruses have been postulated to be capable of triggering the pathogenic process, AD animal models (mouse, pig, and non-human primates) should be controlled for the presence of these viruses. Only virus-free models allow studying the genetic factors and the effect of adding viruses. Roseoloviruses such as human herpesvirus 6 and the related viruses in the animals are the main topic of this commentary.
Keywords: Alzheimer’s disease, animal models, human herpesvirus 6, roseoloviruses
