Affiliations: Department of Neurology, The Catholic University of Korea Seoul St. Mary’s hospital, Seoul, Republic of Korea
Correspondence:
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Correspondence to: Correspondence to: Dong-Won Yang, Department of Neurology, The Catholic University of Korea Seoul St. Mary’s hospital, 222, Banpo-daero, Seocho-gu, Main building 10th floor, Seoul, Republic of Korea. Tel.: +82 2 2258 2816; E-mail: neuroman@catholic.ac.kr.
Abstract: Background:The apolipoprotein E (APOE) ɛ4 allele is a well-known risk factor for AD and is associated with higher amyloid deposition and earlier dementia onset. However, the relationship between amyloid pathology and the most common APOE allele, ɛ3, has not been well studied. Objective:In this study, we aimed to identify the risk factors predicting amyloid PET positivity in patients with mild cognitive impairment (MCI) and APOE ɛ3/ɛ3 genotypes. Methods:We retrospectively reviewed the medical records of MCI patients with APOE ɛ3/ɛ3 genotypes who underwent amyloid PET scanning. Demographics, neuropsychological tests, and brain MRI were obtained. We analyzed which risk factors could affect amyloid PET positivity in MCI patients with APOE ɛ3/ɛ3 genotypes using logistic regression models. Results:We recruited 171 MCI patients with APOE ɛ3/ɛ3 genotypes in this study. Out of 171 patients, 49 patients (28.65%) showed positive results in the amyloid PET scans. In a multivariate logistic regression model, amyloid positivity was associated with frontal atrophy (OR = 2.63, p = 0.009), and CDR-SOB scores (OR = 2.46, p = 0.013). The odds ratio for amyloid PET positivity in patients older than and equal to 75 years with both frontal atrophy and CDR-SOB scores >1.0 was 3.63. Conclusion:Our study demonstrated that frontal atrophy, high CDR-SOB scores, and old age were risk factors associated with amyloid PET positivity in MCI with APOE ɛ3/ɛ3 genotypes.
