Affiliations: [a] CH des vallées de l’Ariège, Consultations mémoire, Foix, France
| [b]
Univ. Lille, CNRS, CHU Lille, UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, Lille, France
| [c] CERPPS, Centre d’Etudes et de Recherche en Psychopathologie et Psychologie de la Santé, EA7411, Université Jean Jaurès, Toulouse, France
Correspondence:
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Correspondence to: Jean-Pierre Jacus, Consultations mém-oire, Centre hospitalier des vallées de l’Ariège, BP 01, 09017 Foix cedex, France. Tel.: +33 0 6 85 07 64 72; Fax: +33 0 5 61 03 31 75; E-mail: jeanpierrej@chi-val-ariege.fr.
Abstract: This study aimed to provide a model of awareness in Alzheimer’s disease using the stage of the disease as a risk factor. Awareness was assessed using three methods (patient-caregiver discrepancy, prediction-performance discrepancy, clinical rating). Twenty-five healthy control subjects and sixty-one patients participated, with measures of cognition, apathy, depression, and awareness. These measures were introduced into a manual backward regression. Confounding factors impacting at least 15% of the exposure factor estimate were maintained in the model. Except for the prediction performance discrepancy, also presenting cognitive associations, the other awareness assessments suggested a major role of depression and apathy as impacting factors.
