Vitamin E Intake Is Associated with Lower Brain Volume in Haptoglobin 1-1 Elderly with Type 2 Diabetes

Article type: Research Article

Authors: Livny, Abigail^{a; b} | Schnaider Beeri, Michal^{a; c; d} | Heymann, Anthony^{e; f} | Moshier, Erin^g | Berman, Yuval^a | Mamistalov, Mary^a | Shahar, Danit-Rivka^h | Tsarfaty, Galia^{b; i} | Leroith, Derek^j | Preiss, Rachel^f | Soleimani, Laili^c | Silverman, Jeremy M.^c | Bendlin, Barbara B.^k | Levy, Andrew^l | Ravona-Springer, Ramit^{a; i; m; *}

Affiliations: [a] The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel | [b] Division of Diagnostic Imaging, Sheba Medical Center, Tel-Hashomer, Israel | [c] The Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA | [d] Baruch Ivcher School of Psychology, Interdisciplinary Center, Herzliya, Israel | [e] Department of Family Medicine, Tel Aviv University, Tel Aviv, Israel | [f] Maccabi Health Services, Israel | [g] Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA | [h] Ben Gurion University, Beersheba, Israel | [i] Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel | [j] Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA | [k] Wisconsin Alzheimer’s Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA | [l] Rambam Medical Center, Technion, Haifa, Israel | [m] Psychiatric Division, Sheba Medical Center, Tel-Hashomer, Israel

Correspondence: [*] Correspondence to: Ravona-Springer Ramit, MD, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel, 52621. Tel.: +972 52 6666562; E-mail: ramit.ravona@sheba.health.gov.il.

Abstract: Backgrounds:The efficacy of vitamin E in prevention of diabetes-related complications differs by Haptoglobin (Hp) genotype. Objective:To examine the role of Hp genotype in the relationship of vitamin E intake with brain volume in cognitively normal elderly patients with type 2 diabetes. Methods:Brain volumes for the superior, middle, and inferior frontal gyri and for the middle temporal gyrus were generated from structural T1 MRI in 181 study participants (Hp 1-1: n = 24, Hp 2-1: n = 77, Hp 2-2: n = 80). Daily vitamin E intake was assessed using the Food Frequency Questionnaire. Analyses of covariance, controlling for demographic and cardiovascular variables was used to evaluate whether the association of daily vitamin E intake with brain volume was modified by Hp genotype. Results:Average age was 70.8 (SD = 4.2) with 40% females, and mean Mini-Mental State Examination score of 28.17 (SD = 1.90). A significant interaction was found between vitamin E intake and Hp genotype in inferior frontal gyrus’ volume; p = 0.0108. For every 1 microgram increase in vitamin E intake, the volume of the inferior frontal gyrus decreased by 0.955% for Hp 1-1 (p = 0.0348), increased by 0.429% for Hp 2-1 (p = 0.0457), and by 0.077% for Hp 2-2 (p = 0.6318). There were no significant interactions between vitamin E intake and Hp genotype for the middle (p = 0.6011) and superior (p = 0.2025) frontal gyri or for the middle temporal gyrus (p = 0.503). Conclusions:The effect of dietary vitamin E on the brain may differ by Hp genotype. Studies examining the impact of vitamin E on brain-related outcomes should consider Hp genotype.

Keywords: Brain volume, diabetes, haptoglobin genotype, vitamin E

DOI: 10.3233/JAD-191294

Journal: Journal of Alzheimer's Disease, vol. 74, no. 2, pp. 649-658, 2020