Affiliations: [a] Laboratoty of Psychology, Department of Experimental and Cognitive Psychology, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece
| [b] 1st Department of Neurology, Medical School, Aristotle University of Thessaloniki (AUTh), Greece
| [c] Greek Association of Alzheimer’s Disease and Related Disorders, Thessaloniki (GAADRD), Greece
| [d] Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI), AUTh, Greece
Correspondence:
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Correspondence to: Glykeria Tsentidou, School of Psychology, Aristotle University of Thessaloniki, Greece. Tel.: +30 698 3140302; E-mail: gtsentid@psy.auth.gr.
Abstract: Cardiovascular health declines with age, due to vascular risk factors, and this leads to an increasing risk of cognitive decline. Mild cognitive impairment (MCI) is defined as the negative cognitive changes beyond what is expected in normal aging. The purpose of the study was to compare older adults with vascular risk factors (VRF), MCI patients, and healthy controls (HC) in main dimensions of cognitive control. The sample comprised a total of 109 adults, aged 50 to 85 (M = 66.09, S.D. = 9.02). They were divided into three groups: 1) older adults with VRF, 2) MCI patients, and 3) healthy controls (HC). VRF and MCI did not differ significantly in age, educational level, or gender as was the case with HC. The tests used mainly examine inhibition, cognitive flexibility, and working memory processing. Results showed that the VRF group had more Set Loss Errors in drawing designs indicating deficits in establishing cognitive set and in cognitive shifting. MCI patients displayed lower performance in processing. Hence, different types of specific impairments emerge in vascular aging and MCI, and this may imply that discrete underlying pathologies may play a role in the development of somewhat different profiles of cognitive decline.
Keywords: Cardiovascular risk factors, cognitive impairment, inhibitory control, vascular hypothesis of cognitive aging, visuospatial ability, working memory
