A Novel Detection Tool for Mild Cognitive Impairment Patients Based on Eye Movement and Electroencephalogram

Article type: Research Article

Authors: Jiang, Juanjuan^{a; b; 1} | Yan, Zhuangzhi^b | Sheng, Can^{d; 1} | Wang, Min^{a; b} | Guan, Qinglan^c | Yu, Zhihua^{c; *} | Han, Ying^{d; e; f; g; *} | Jiang, Jiehui^{a; b; *}

Affiliations: [a] Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China | [b] Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, Shanghai, China | [c] Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China | [d] Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China | [e] Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China | [f] Beijing Institute of Geriatrics, Beijing, China | [g] National Clinical Research Center for Geriatric Disorders, Beijing, China

Correspondence: [*] Correspondence to: Jiehui Jiang, PhD, Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, 99 Shangda Road, Shanghai 200444, China. E-mail: jiangjiehui@shu.edu.cn and Ying Han, MD, PhD, Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China. Tel.: +86 18515692701; Fax: +86 10 83167306; E-mail: hanying@xwh.ccmu.edu.cn and ZhihuaYu, MD, Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 265 South Xiangyang Road, Shanghai, 200031, China. E-mail: yzh119@hotmail.com.

Note: [1] These authors have contributed equally to this work.

Abstract: Background:Detecting subtle changes in visual attention from electroencephalography (EEG) and the perspective of eye movement in mild cognitive impairment (MCI) patients can be of great significance in screening early Alzheimer’s disease (AD) in a large population at primary care. Objective:We proposed an automatic, non-invasive, and quick MCI detection approach based on multimodal physiological signals for clinical decision-marking. Methods:The proposed model recruited 152 patients with MCI and 184 healthy elderly controls (HC) who underwent EEG and eye movement signal recording under a visual stimuli task, as well as other neuropsychological assessments. Forty features were extracted from EEG and eye movement signals by linear and nonlinear analysis. The features related to MCI were selected by logistic regression analysis. To evaluate the efficacy of this MCI detection approach, we applied the same procedures to achieve the Clinical model, EEG model, Eye movement model, EEG+ Clinical model, Eye movement+ Clinical model, and Combined model, and compared the classification accuracy between the MCI and HC groups with the above six models. Results:After the penalization of logistic regression analysis, five features from EEG and eye movement features exhibited significant differences (p < 0.05). In the classification experiment, the combined model resulted in the best accuracy. The average accuracy for the Clinical/EEG/Eye movement/EEG+ Clinical/Eye movement+ Clinical/Combined model was 68.69%, 61.79%, 73.13%, 69.46%, 75.61%, and 81.51%, respectively. Conclusion:These results suggest that the proposed MCI detection tool has the potential to screen MCI patients from HCs and may be a powerful tool for personalized precision MCI screening in the large-scale population under primary care condition.

Keywords: Attention, electroencephalography, eye movement, mild cognitive impairment, multimodal detection

Keywords: 2017LCSY345

DOI: 10.3233/JAD-190628

Journal: Journal of Alzheimer's Disease, vol. 72, no. 2, pp. 389-399, 2019