Common Variants in ABI3 Influence Cerebrospinal Fluid Total Tau Levels and Cognitive Decline in Progressive Mild Cognitive Impairment Patients

Article type: Short Communication

Authors: Niu, Li-Dong^{a; 1} | Yin, Rui^{b; 1} | Li, Jie-Qiong^a | Cao, Xi-Peng^c | Yu, Jin-Tai^{d; *} | Tan, Lan^{a; *} | Alzheimer’s Disease Neuroimaging Initiative²

Affiliations: [a] Department of Neurology, Qingdao Municipal Hospital, Qingdao University, China | [b] Clinical Medicine, Queen Mary School, Nanchang University, Nanchang, Jiangxi, China | [c] Clinical Research Center, Qingdao Municipal Hospital, Qingdao University, China | [d] Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

Correspondence: [*] Correspondence to: Jin-Tai Yu, MD, PhD, Department of Neurology, Huashan Hospital, Fudan University, No. 12 Wulumuqi Road, Shanghai, China. Tel.:/Fax: +86 532 8890 5659; Email:  Email: yu-jintai@163.com and Lan Tan, MD, PhD, Department of Neurology, Qingdao Municipal Hospital, Qingdao University, No.5 Donghai Middle Road, Qingdao, China. Email: dr.tanlan@163.com.

Note: [] 1These authors contributed equally to this work.

Note: [] 2Data used in preparation for this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (http://adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in the analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf.

Abstract: A potential role for ABI3 gene has been suggested in the risk of Alzheimer’s disease (AD), but the detailed mechanism before typical AD onset was unclear. In this study, we investigated the associations of ABI3 common variants with cerebrospinal fluid biomarkers and cognitive function scores among non-demented elderly from the ADNI database. We found that, in the progressive mild cognitive impairment group, rs5978930 was associated with total tau levels and rs16947151 was associated with cognitive function scores at baseline and over time, suggesting that ABI3 variants may be associated with cognitive decline and may influence AD onset through tau pathology.

Keywords: ABI3, biomarkers, mild cognitive impairment, total tau, variant

DOI: 10.3233/JAD-190153

Journal: Journal of Alzheimer's Disease, vol. 70, no. 1, pp. 17-23, 2019