Reliability and Validity of the Chinese Version of the Mild Behavioral Impairment Checklist for Screening for Alzheimer’s Disease

Article type: Research Article

Authors: Cui, Yue^a | Dai, Sisi^a | Miao, Zupei^a | Zhong, Yu^a | Liu, Yang^a | Liu, Lin^a | Jing, Donglai^a | Bai, Yanyan^a | Kong, Yu^a | Sun, Wei^a | Li, Fang^b | Guo, Qihao^c | Rosa-Neto, Pedro^d | Gauthier, Serge^d | Wu, Liyong^{a; e; *}

Affiliations: [a] Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China | [b] Department of Geriatric, Fu Xing Hospital, Capital Medical University, Beijing, China | [c] Department of Gerontology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, China | [d] Alzheimer’s Disease Research Unit, McGill Centre for Studies in Aging, Verdun, QC, Canada | [e] National Clinical Research Center for Geriatric Disorders, Capital Medical University, Beijing, China

Correspondence: [*] Correspondence to: Dr. Liyong Wu, Department of Neurology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China. Tel.: +86 13683120871; E-mail: wmywly@hotmail.com.

Abstract: Background:The Mild Behavioral Impairment Checklist (MBI-C), a screening scale for neuropsychiatric symptom evaluation, facilitates Alzheimer’s disease (AD) screening. However, its validity and reliability for use as an AD screening tool have not been determined. Objective:To develop an AD screening scale suitable for the Chinese population. Methods:The MBI-C was translated into Chinese and back-translated with the original author’s consent. Forty-six AD patients, attending the Xuanwu hospital memory clinic, and 50 sex- and education-matched controls from the community underwent a full neuropsychological evaluation, including MBI-C assessment. Among them, 15 AD patients were evaluated repeatedly, and eight were evaluated simultaneously by two different clinicians, to assess MBI-C reliability. Results:The MBI-C demonstrated good internal consistency reliability, test–retest reliability, and inter-rater reliability. Its optimal cutoff point was 6/7 for identifying AD dementia, with a sensitivity of 86.96% and specificity of 86.00%, and its detection rate for moderate–severe AD dementia was higher than that of the Neuropsychiatric Inventory Questionnaire (NPI-Q). Pearson’s correlation coefficients ranged from 0.702 to 0.831, indicating content validity. Seven factors were extracted during principal component analysis, with a cumulative contribution of 70.55%. Moreover, the Pearson’s correlation coefficient was 0.758, indicating its criterion validity. The MBI-C could also distinguish AD dementia severity. MBI-C scores were significantly negatively correlated with MMSE and MoCA scores, and positively correlated with ADL scores. Conclusion:This study showed that the Chinese version of MBI-C has high reliability and validity, and could replace the NPI-Q for AD dementia screening in the Chinese population.

Keywords: Alzheimer’s disease, mild behavioral impairment checklist, neuropsychiatric inventory questionnaire, reliability, validity

DOI: 10.3233/JAD-190113

Journal: Journal of Alzheimer's Disease, vol. 70, no. 3, pp. 747-756, 2019