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Article type: Review Article
Authors: Manigrasso, Maurizioa; * | Protano, Carmelab | Vitali, Matteob | Avino, Pasqualec
Affiliations: [a] Department of Technological Innovations, INAIL, Rome, Italy | [b] Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy | [c] Department of Agricultural, Environmental and Food Sciences (DiAAA), University of Molise, Campobasso, Italy
Correspondence: [*] Correspondence to: Maurizio Manigrasso, Department of Technological Innovations, INAIL, Via IV Novembre 144, 00187 Rome, Italy. Tel.: +39 06 5487 6418; E-mail: m.manigrasso@inail.it.
Abstract: This paper presents an overview of the literature studies on the sources of ultrafine particles (UFPs), nanomaterials (NMs), and nanoparticles (NPs) occurring in indoor (occupational and residential) and outdoor environments. Information on the relevant emission factors, particle concentrations, size, and compositions is provided, and health relevance of UFPs and NPs is discussed. Particular attention is focused on the fraction of particles that upon inhalation deposit on the olfactory bulb, because these particles can possibly translocate to brain and their possible role in neurodegenerative diseases is an important issue emerging in the recent literature.
Keywords: Health relevance, indoor, nanomaterials, neurodegenerative diseases, outdoor, ultrafine particles
DOI: 10.3233/JAD-181266
Journal: Journal of Alzheimer's Disease, vol. 68, no. 4, pp. 1371-1390, 2019
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