The Potential Role of Dysregulated miRNAs in Alzheimer’s Disease Pathogenesis and Progression

Article type: Review Article

Authors: Patel, Ankur A.^a | Ganepola, Ganepola A.P.^a | Rutledge, John R.^b | Chang, David H.^{a; *}

Affiliations: [a] Department of Research, Center for Cancer Research and Genomic Medicine, The Valley Hospital, Paramus, NJ, USA | [b] Department of Oncology Special Program, The Daniel and Gloria Blumenthal Cancer Center, The Valley Hospital, Paramus, NJ, USA

Correspondence: [*] Correspondence to: David H. Chang, Center for Cancer Research and Genomic Medicine, Department of Research, the Valley Hospital, 970 Linwood Avenue, Paramus, NJ 07652, USA. Tel.: +1 201 389 0208; E-mail: davidhc9@gmail.com.

Abstract: Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that affects the cognitive faculties of millions of people worldwide. There is still no known cure for AD, nor a clear understanding of AD etiology. Nevertheless, researchers have made significant strides in understanding various key aspects of AD neuropathology at the cellular and molecular levels. This review is intended to provide a general survey of what is known and unknown, based on the three hallmarks of AD, combined with our knowledge from microRNA research. Our goal is to reevaluate and reassess the current direction of AD research and therapeutic insights, charting a new course and comprehensive plan to combat this imminent global health threat.

Keywords: Alzheimer’s disease, amyloid-β protein precursor, circulating microRNA, cognition disorders, gene expression regulation, long-term memory, long-term potentiation, neurofibrillary tangles, synaptic potentials, tauopathy

DOI: 10.3233/JAD-181078

Journal: Journal of Alzheimer's Disease, vol. 67, no. 4, pp. 1123-1145, 2019