Affiliations: [a] Wien Center for Alzheimer’s Disease & Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA
| [b] Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
| [c] Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, FL, USA
| [d] Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA
Correspondence:
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Correspondence to: Ranjan Duara, Wien Center for Alzheimer’s Disease & Memory Disorder, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA. Tel.: +1 786 328 4069; E-mail: ranjan.duara@msmc.com.
Abstract: Background:The impact of amyloid positron emission tomography (Aβ-PET) in a “real-world” memory disorders clinic remains poorly studied. Objective:We studied the impact of Aβ-PET in diagnosis and management in the memory clinic and factors making the most impact in diagnosis and management. Methods:We studied 102 patients who had presented at a memory disorders clinic (the Wien Center for Alzheimer’s Disease and Memory Disorders, Miami Beach, FL) and had a diagnostic work-up for cognitive complaints, including Aβ-PET scans. Results:Following Aβ-PET, changes were made in diagnosis (37.3%), in specific treatments for Alzheimer’s disease (26.5%) and in psychiatric treatments (25.5%). The agreement between diagnosis pre-Aβ-PET versus post-Aβ-PET diagnosis was only fair, with a Cohen’s kappa of 0.23 (95% CI 0–0.42). Patients with MRI findings suggestive of AD (medial temporal and/or parietal atrophy) were more frequently amyloid positive than amyloid negative (66.2% versus 33.8%, p = 0.04). Among patients with atypical clinical features for AD, but with MRI findings suggestive of AD, an amyloid negative PET scan had a greater impact than an amyloid positive PET scan on diagnosis (84.2% versus 17.1%, p < 0.001), management (84.2% versus 40%, p < 0.01) and discussion of results and advice on lifestyle (73.7% versus 22.9%, p < 0.001). Conclusions:We conclude that MRI features suggestive of AD predict a positive amyloid PET scan. However, among those with MRI features suggestive of AD but with atypical clinical features of AD, the clinical impact on diagnosis and management is greater for an amyloid negative than an amyloid positive Aβ-PET scans.
