Affiliations: [a] Cognitive Impairment Center, Local Health Autority n.2 Marca Trevigiana, Treviso, Italy
| [b] University of Milan, Centro Dino Ferrari, Milan, Italy
| [c] Fondazione IRCSS Ca’ Granda, Ospedale Policlinico, Neurodegenerative Diseases Unit, Milan, Italy
Correspondence:
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Correspondence to: Maria Elena Di Battista, MD, Cognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy. E-mail: mariaelena.dibattista@aulss2.veneto.it.
Abstract: We describe the case of a 61-year-old woman diagnosed with Borreliosis at the age of 57. Subsequently, the patient developed depression, anxiety, and behavioral disturbances. A lumbar puncture excluded the condition of Neuroborreliosis. The diagnostic workup included: an MRI scan, a 18F-FDG PET, a 123I-ioflupane-SPECT, an amyloid-β PET, a specific genetic analysis, and a neuropsychological evaluation. Based on our investigation, the patient was diagnosed with probable behavioral-frontotemporal dementia (bvFTD), whereas in the previous years, the patient had been considered firstly as a case of Post-Treatment-Lyme Disease and, secondly, a psychiatric patient. We believe that, in the present case, such initial symptoms of Borrelia infection may have superimposed on those of bvFTD rather than playing as a contributory cause.
