Affiliations: [a] Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
| [b] Department of Surgery and Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA, USA
Correspondence:
[*]
Correspondence to: Nelson Arispe, PhD, Department of Anatomy, Physiology and Genetics, Uniformed Services University, 4301 Jones Bridge Road, Bldg. B, Room B2054, Bethesda, MD 20814-4799, USA. Tel.: +1 301 295 9367; E-mail: Nelson.arispe@usuhs.edu.
Abstract: Alzheimer’s disease (AD) is a major contemporary and escalating malady in which amyloid-β (Aβ) peptides are the most likely causative agent. Aβ peptides spontaneously tend to aggregate in extracellular fluids following a progression from a monomeric state, through intermediate forms, ending in amyloid fibers and plaques. It is generally accepted now that the neurotoxic agents leading to cellular death, memory loss, and other AD characteristics are the Aβ intermediate aggregated states. However, Aβ peptides are continuously produced, released into the extracellular space, and rapidly cleared from healthy brains. Coincidentally, members of the heat shock proteins (hsp) family are present in the extracellular medium of healthy cells and body fluids, opening the possibility that hsps and Aβ could meet and interact in the extracellular milieu of the brain. In this perspective and reflection article, we place our investigation showing that the presence of Hsp70s mitigate the formation of low molecular weight Aβ peptide oligomers resulting in a reduction of cellular toxicity, in context of the current understanding of the disease. We propose that it may be an inverse relationship between the presence of Hsp70, the stage of Aβ oligomers, neurotoxicity, and the incidence of AD, particularly since the expression and circulating levels of hsp decrease with aging. Combining these observations, we propose that changes in the dynamics of Hsp70s and Aβ concentrations in the circulating brain fluids during aging defines the control of the formation of Aβ toxic aggregates, thus determining the conditions for neuron degeneration and the incidence of AD.
Keywords: Aging, Alzheimer’s disease, heat shock proteins, neurotoxicity, protein oligomerization
