The Uniform Data Set, Czech Version: Normative Data in Older Adults from an International Perspective

Article type: Research Article

Authors: Nikolai, Tomas^{a; *} | Stepankova, Hana^b | Kopecek, Miloslav^b | Sulc, Zdenek^b | Vyhnalek, Martin^{c; d} | Bezdicek, Ondrej^{a; b}

Affiliations: [a] Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital in Prague, Czech Republic | [b] National Institute of Mental Health, Klecany, Czech Republic | [c] International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic | [d] Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Czech Republic

Correspondence: [*] Correspondence to: Tomas Nikolai, PhD, Department of Neurology and Centre of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Kateřinská 30, 128 21 Praha 2, Czech Republic. Tel.: +420 224 965 524/731 478 794; Fax: +420 224 922 678; E-mail: nikolai@centrum.cz.

Abstract: Background:Outside of the United States, international perspectives on normative data for neuropsychological test performance, within diverse populations, have been scarce. The neuropsychological test battery from the Uniform Data Set (UDS) of the Alzheimer’s Disease Centers (ADC) program of the United States National Institute on Aging (NIA) is one of the most sensitive batteries for the evaluation of both normal cognitive aging and pathological cognitive decline. Objective:This study aimed to determine the feasibility of the Czech Neuropsychological Test Battery from the Uniform Data Set (UDS-Cz 2.0), while also evaluating the results obtained from an international perspective. Methods:This paper describes data from 520 cognitively normal participants. Regression analyses were used to describe the influence of demographic variables on UDS-Cz test performance. Results:Cognitive performance on all measures declined with age, with patient education level serving as a protective factor. Therefore, the present study provides normative data for the UDS-Cz, adjusted for the demographic variables of age and education. Conclusion:The present study determines the psychometric properties of the UDS-Cz and establishes normative values in the aging Czech population, which can be used in clinical settings.

Keywords: Aging, Alzheimer’s disease, healthy subjects, normative

DOI: 10.3233/JAD-170595

Journal: Journal of Alzheimer's Disease, vol. 61, no. 3, pp. 1233-1240, 2018