Prevalence, Risk Factors, and Complaints Screening Tool Exploration of Subjective Cognitive Decline in a Large Cohort of the Chinese Population

Article type: Research Article

Authors: Hao, Lixiao^a | Wang, Xiaoni^b | Zhang, Ling^d | Xing, Yue^{e; f} | Guo, Qihao^g | Hu, Xiaochen^h | Mu, Bin^b | Chen, Yiliⁱ | Chen, Guanqun^b | Cao, Jing^j | Zhi, Xiaodong^k | Liu, Jiaojiao^l | Li, Xuanyu^b | Yang, Liu^b | Li, Jiachen^b | Du, Wenying^b | Sun, Yu^b | Wang, Ting^a | Liu, Zhen^m | Liu, Zheng^d | Zhao, Xuexue^a | Li, Hongyanⁿ | Yu, Yang^o | Wang, Xue^t | Jia, Jianguo^{p; *} | Han, Ying^{b; c; q; r; s; *}

Affiliations: [a] Department of General Practice, School of General Practice and Continuing Education of Capital Medical University, Beijing, China | [b] Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China | [c] Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China | [d] Department of Epidemiology and Health Statistics, School of Public Health of Capital Medical University, Beijing, China | [e] Radiological Sciences, Division of Clinical Neuroscience, Queen’s Medical Centre, University of Nottingham, Nottingham, UK | [f] Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, UK | [g] Department of Neurology, Huashan Hospital of Fudan University, Shanghai, China | [h] Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany | [i] Department of Neurology, Dali People’s Hospital, Yunnan, China | [j] Department of Neurology, Hong Xinglong Center Hospital, Heilongjiang, China | [k] Department of Neurology, Lanzhou General Hospital of Lanzhou Military Command, Gansu, China | [l] Department of Radiology, Youan Hospital of Capital Medical University, Beijing, China | [m] Department of General Practice, XuanWu Hospital of Capital Medical University, Beijing, China | [n] Department of Neurology, Civil Aviation General Hospital, Beijing, China | [o] Department of Neurology, Hongqi Hospital of Mudanjiang Medical University, Heilongjiang, China | [p] Department of General Surgery, XuanWu Hospital of Capital Medical University, Beijing, China | [q] Beijing Institute of Geriatrics, Beijing, China | [r] National Clinical Research Center for Geriatric Disorders, Beijing, China | [s] PKU Care Rehabilitation Hospital, Beijing, China | [t] Department of Library, XuanWu Hospital of Capital Medical University, Beijing, China

Correspondence: [*] Correspondence to: Jianguo Jia, Department of General Surgery, XuanWu Hospital of Capital Medical University, Beijing, China. Tel.: +86 13701152053; E-mail: jiajianguo_1@126.com. and Ying Han, Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China. Tel.: +86 13621011941; E-mail: hanying@xwh.ccmu.edu.cn.

Abstract: Background: Substantial studies have reported the prevalence and the affecting factors of subjective cognitive decline (SCD). The complaints screening scale has also been used for probing. However, little is known in China. Objective:To investigate the prevalence and risk factors of SCD, and explore an SCD complaints screening scale in China. Methods:Stratified cluster random sampling was conducted. 2,689 residents aged 60–80 years completed questionnaire 1. 814 residents were included for clinical and neuropsychological evaluations. Two standards were used to make the diagnosis of mild cognitive impairment (MCI) and SCD, and a preliminary screening rate comparison was carried out. Finally, we assessed the risk factors of SCD and the correlation between the SCD-questionnaire 9 (SCD-Q9) and the Auditory Verbal Learning Test-Long Delay Free Recall (AVLT-LR). Results:1) Standard 1 (ADNI2): the prevalence of SCD was 18.8% (95% CI = 14.7–22.9%) and zero conformed to six criteria (SCD plus). 2) Standard 2 (Jak/Bondi): the prevalence of SCD was 14.4% (95% CI = 10.7–18.1%). 3) Standard 1 had a relatively higher “false” positive rate, whereas Standard 2 had higher “false” negative rate. 4) Age, low education, fewer close friends, and daily drinking were independent risk factors for SCD progressing to MCI. 5) Total points of SCD-Q9 were negatively correlated to the value of AVLT-LR. Conclusions:The prevalence of SCD is high in the ShunYi District in Beijing, China. Age, low education, less social support, and daily drinking are independent risk factors. The brief SCD-Q9 can be used as a reference.

Keywords: Alzheimer’s disease, prevalence, risk factors, SCD-Q9, subjective cognitive decline

DOI: 10.3233/JAD-170347

Journal: Journal of Alzheimer's Disease, vol. 60, no. 2, pp. 371-388, 2017