Affiliations: [a] College of Medicine, Kangwon National University, Chuncheon, Republic of Korea
| [b] Department of Neurology, Kangwon National University Hospital, Chuncheon, Republic of Korea
| [c] Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
| [d] Department of Neurology, Seoul National University College of Medicine, Seoul, Korea
| [e] Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea
| [f] Department of Neurology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea
Correspondence:
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Correspondence to: Jae-Won Jang, MD, Kangwon National University Hospital, 156 Baengnyeong, Chuncheon, Kangwon, 200-722, Korea. Tel.: +82 33 258 9174; Fax: +82 33 258 2103; E-mail: light26@kangwon.ac.kr.
Note: [1] Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (http://adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf.
Abstract: Background: Depressive symptoms are prevalent in patients with mild cognitive impairment (MCI) and are considered to be a risk factor for progression to dementia. Objective: The purpose of this study was to evaluate whether depressive symptoms in MCI promote disease progression in a manner related to amyloid status, and to determine the relationship between depressive symptoms and longitudinal cerebral structural changes. Methods: Baseline data for 336 patients with MCI (75 with depression and 261 without) from the Alzheimer’s Disease Neuroimaging Initiative study were analyzed. All participants underwent comprehensive cognitive testing, volumetric magnetic resonance imaging (MRI), and [18F]AV45 positron emission tomography amyloid imaging. Depressive symptoms were measured using the Neuropsychiatric Inventory Questionnaire. A voxel-based morphometric analysis using volumetric brain MRI data was used to compare longitudinal structural changes related to depressive symptoms. Results: The conversion rate to dementia was different between patients with and without depression in amyloid-positive MCI (40.8% versus 19.7%, respectively; p = 0.006). Patients who were amyloid-positive at baseline also exhibited a greater degree of 2-year cognitive decline. Depression in amyloid-positive MCI was associated with longitudinal cortical atrophy in the left cingulate gyrus. Conclusion: Our study indicates that the presence of depressive symptoms in patients with amyloid-positive MCI is associated with higher progression to dementia and longitudinal cortical atrophy.
