¹⁸F-AV-1451 PET Imaging in Three Patients with Probable Cerebral Amyloid Angiopathy

Article type: Short Communication

Authors: Kim, Hee Jin^{a; b} | Cho, Hanna^c | Werring, David J.^d | Jang, Young Kyoung^{a; b} | Kim, Yeo Jin^{a; b; e} | Lee, Jin San^f | Lee, Juyoun^{a; b; g} | Jun, Soomin^{a; b} | Park, Seongbeom^{a; b} | Ryu, Young Hoon^h | Choi, Jae Yong^h | Cho, Young Seokⁱ | Moon, Seung Hwanⁱ | Na, Duk L.^{a; b; j} | Lyoo, Chul Hyoung^c | Seo, Sang Won^{a; b; j; k; *}

Affiliations: [a] Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea | [b] Neuroscience Center, Samsung Medical Center, Seoul, Korea | [c] Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea | [d] Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK | [e] Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea | [f] Department of Neurology, Kyung Hee University Hospital, Seoul, Korea | [g] Department of Neurology, School of Medicine, Chungnam National University Hospital, Daejeon, Korea | [h] Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea | [i] Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea | [j] Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea | [k] Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea

Correspondence: [*] Correspondence to: Sang Won Seo, MD, PhD, Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea. Tel.: +82 2 3410 1233; Fax: +82 2 3410 0052; E-mail: sangwonseo@empal.com.

Abstract: Cerebrovascular deposition of amyloid-β, known as cerebral amyloid angiopathy (CAA), is associated with MRI findings of lobar hemorrhage, cerebral microbleeds, and cortical superficial siderosis. Although pathological studies suggest that tau may co-localize with vascular amyloid, this has not yet been investigated in CAA in vivo. Three patients with probable CAA underwent 11C-Pittsburgh Compound B (PiB) PET or 18F-florbetaben PET to evaluate amyloid burden, and 18F-AV-1451 PET to evaluate paired helical filament tau burden. Regions that had cerebral microbleeds or cortical superficial siderosis largely overlapped with those showing increased 18F-AV-1451. Our preliminary study raised the possibility that lobar cerebral microbleeds, and cortical superficial siderosis, which are characteristic markers of vascular amyloid, may be associated with local production of paired helical filament tau.

Keywords: Cerebral amyloid angiopathy, cortical superficial siderosis, ¹⁸F-AV-1451 PET, lobar cerebral microbleeds, tau

DOI: 10.3233/JAD-161139

Journal: Journal of Alzheimer's Disease, vol. 57, no. 3, pp. 711-716, 2017