Affiliations: [a] Institute of Clinical Medicine–Neurology, University of Eastern Finland, Kuopio, Finland
| [b] Research Center for Comparative Effectiveness and Patient Safety (RECEPS) and School of Pharmacy, University of Eastern Finland, Kuopio, Finland
| [c]
Karolinska Institutet Center for Alzheimer Research, Stockholm, Sweden
| [d] Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland
| [e] Department of Neurology, University of Eastern Finland, Kuopio, Finland
| [f]
National Institute for Health and Welfare, Helsinki, Finland
| [g] Aging Research Center (ARC) and center for Alzheimer Research, Karolinska Institutet and Stockholm University, Stockholm, Sweden
Correspondence:
[*]
Correspondence to: Bushra Imtiaz, Department of Neurology, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland. Tel.: +358 4433 06675; E-mail: bushra.imtiaz@uef.fi.
Abstract: Cardiovascular Risk factors, Aging and Dementia (CAIDE) is a Finnish population-based study. 731 cognitively normal women had self-reported hormone therapy (HT) data in 1998 as: no use, use ≤5 years, and >5 years. Information on type of HT was only available from 1995–1998 (Prescription Register). Cognition was assessed in 1998 and 2005–2008. Long-term (>5 years) HT use, especially use of estradiol alone among women having hysterectomy with bilateral oophorectomy, was associated with better episodic memory in 1998, but not in 2005–2008. Although a strong evidence for protective effect of estradiol on cognition was not observed in our study, improved global cognition among long-term users suggests that long-term postmenopausal HT may be beneficial for some cognitive domains.
