Affiliations: School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ, USA
Correspondence:
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Correspondence to: Brendan J. Miller, School of Nutrition and Health Promotion, Arizona State University, 425 N. 5th Street, Phoenix, AZ 85004, USA. Tel.: +1 480 580 0099; E-mail: Brendan.Miller@asu.edu.
Abstract: Low plasma amyloid-β (Aβ) is linked to Alzheimer’s disease. Since vitamin D cleared brain Aβ in vitro, this 8-week trial examined whether vitamin D increased plasma Aβ40. Vitamin D insufficient adults (6/18 M/F; 64.3 ± 10.9 y) were randomized to placebo or vitamin (50,000 IU/week) treatments. The vitamin group experienced greater plasma Aβ40 change than controls, +14.9 ± 12.0 and +12.8 ± 12.8 pg/mL (p = 0.045; effect size, 0.228). Change in Aβ40 for older participants (≥60 y) was +18.3 ± 33.6 and –3.2 ± 44.5 pg/mL for vitamin (n = 4) and placebo (n = 4) groups (effect size, 0.295). Thus, vitamin D may increase plasma Aβ, particularly in older adults, suggesting decreased brain Aβ.
Keywords: Alzheimer’s disease, amyloid-β, P-glycoprotein, plasma Aβ, vitamin D
