Affiliations: [a] Department of Neurology, Azienda Universitaria-Ospedaliera of Cagliari and University of Cagliari, Cagliari, Italy | [b] Department of Radiology, Azienda Universitaria-Ospedaliera of Cagliari and University of Cagliari, Cagliari, Italy | [c] Multiple Sclerosis Centre, University of Cagliari, Cagliari, Italy
Correspondence:
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Correspondence to: Gianluca Floris, Department of Neurology, University of Cagliari, Sst 554, 10126 Monserrato, Italy. Tel.: +39 070 51096043; Fax: +39 070 51096497; lgr.floris@tiscali.it
Abstract: Cerebral microbleeds (CMB) might reflect specific underlying vascular pathologies like cerebral amyloid angiopathy (CAA). In the present study we report the gradient-echo MRI pattern of two siblings with P284S PSEN1 mutation. T2* gradient-echo images of the two subjects demonstrated multiple microbleeds in lobar regions. The role and causes of CMB in sporadic Alzheimer’s disease (AD) patients have not been clearly established and useful contributions could derive from familial AD studies. Furthermore, since CAA is a potential risk factor for developing adverse events in AD immunization trials, the identification in vivo of CAA through non-invasive MRI methods could be useful to monitoring side effects.
