Affiliations: [a] University of Magdeburg, Department of Neurology, Magdeburg, Germany | [b] Saarland University Medical School, José Carreras Center for Immuno- and Gene Therapy and Internal Medicine I, Homburg/Saar, Germany
Correspondence:
[*]
Correspondence to: Daniel M. Bittner, MD, University of Magdeburg, Department of Neurology, Leipziger Str. 44, 39120 Magdeburg, Germany. Tel.: +49 391 6724555; Fax: +49 391 6724526; daniel.bittner@med.ovgu.de
Note: [1] The statistical analysis was conducted by Daniel Bittner.
Abstract: Background: Analysis of cerebrospinal fluid (CSF) has improved over the last few years; thus specific markers for different diseases have emerged, e.g., amyloid-β (Aβ) for Alzheimer’s disease (AD) and progranulin for frontotemporal dementia (FTD). Objective: Evaluation of correlation between biomarkers in CSF and cognitive performance in populations with AD and FTD. Methods: 27 patients with AD and 16 with FTD were included. CSF tau, P-tau181P, Aβ42, and progranulin (PGRN) were measured and a standardized neuropsychological test battery applied. Olfactory testing was additionally included where available. Results: For all patients across both groups, an association between PGRN and categoric (p = 0.016) and letter fluency (p = 0.029), naming (p = 0.003), and overall cognition (Mini-Mental State Examination: p = 0.04) was observed. Aβ42 was strongly associated with memory function (learning: p = 0.001; recall: p = 0.002). A correlation between Aβ42 and memory performance was moreover found for each group separately, while PGRN also showed a correlation with recognition memory (p = 0.04) in AD. Furthermore, an association between reduced PGRN and olfactory dysfunction was revealed (p = 0.01). Conclusions: CSF-levels of PGRN and Aβ42 levels express deficits in cognition differentially, with PGRN being predominantly associated with frontal and Aβ42 with temporal dysfunction. This mirrors the cerebral occurrence of these proteins. These associations appear to be consistent across both disease groups. The relationship between PGRN and olfaction further underpins the association between PRGN and frontal dysfunction.
