Affiliations: [a] Department of Neurology, University of Szeged, Szeged, Hungary | [b] International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic | [c] MTA-SZTE Neuroscience Research Group, Szeged, Hungary
Correspondence:
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Correspondence to: Professor László Vécsei, Director, Department of Neurology, Albert Szent-Györgyi Clinical Center, Faculty of Medicine, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary. Tel.: +36 62 545351/545348; Fax: +36(62)545597;vecsei.laszlo@med.u-szeged.hu
Abstract: The importance of imaging biomarkers has been acknowledged in the diagnosis and in the follow-up of Alzheimer’s disease (AD), one of the major causes of dementia. Next to the molecular biomarkers and PET imaging investigations, structural MRI approaches provide important information about the disease progression and about the pathomechanism. Furthermore,a growing body of literature retranslates these imaging biomarkers to various rodent models of the disease. The goal of this review is to provide an overview of the macro- and microstructural imaging biomarkers of AD, concentrating on atrophy measures and diffusion MRI alterations. A survey is also given of the imaging approaches used in rodent models of dementias that can promote drug development.
Keywords: Alzheimer’s disease, diffusion tensor imaging, magnetic resonance imaging, rodent model
