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Shorter Adult Height is Associated with Poorer Cognitive Performance in Elderly Men with Type II Diabetes

Article type: Research Article

Authors: West, Rebecca K.a; * | Ravona-Springer, Ramitb | Heymann, Anthonyd | Schmeidler, Jamesa | Leroith, Dereke | Koifman, Kerenb | Guerrero-Berroa, Elizabetha | Preiss, Rachelb | Hoffman, Hadasb | Silverman, Jeremy M.a; c | Beeri, Michal Schnaidera; b

Affiliations: [a] Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA | [b] The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel | [c] James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA | [d] Maccabi Healthcare Services, Tel-Aviv, Israel | [e] Division of Medicine, Endocrinology, Diabetes, and Bone Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Correspondence: [*] Correspondence to: Rebecca West, M.A., Department of Psychiatry, Box 1230, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1230, New York, NY 10029, USA. Tel.: +1 212 659 5603; Fax: +1 212 659 5626; E-mail: rebecca.west@mssm.edu.

Keywords: Cognitive performance, height, risk factors, type 2 diabetes mellitus, vascular dementia

DOI: 10.3233/JAD-142049

Journal: Journal of Alzheimer's Disease, vol. 44, no. 3, pp. 927-935, 2015

Accepted 1 October 2014
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Published: 6 February 2015
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Abstract

We studied the relationship of adult body height with five cognitive outcomes (executive functioning, semantic categorization, attention/working memory, episodic memory, and an overall cognition measure) in 897 cognitively normal elderly with type 2 diabetes. Regression analyses controlling for sociodemographic, cardiovascular, and diabetes-related risk factors and depression demonstrated that in males, shorter stature was associated with poorer executive functioning (p = 0.001), attention/working memory (p = 0.007), and overall cognition (p = 0.016), but not with episodic memory (p = 0.715) or semantic categorization (p = 0.948). No relationship between height and cognition was found for females. In cognitively normal type 2 diabetes male subjects, shorter stature, a surrogate for early-life stress and poor nutrition, was associated with cognitive functions.

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