Affiliations: [a] Laboratoire Nutrition, Aliments Fonctionnels et Santé Vasculaire, UR12ES05 Université de Monastir, Tunisia | [b] Equipe Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique EA 7270/Université de Bourgogne/INSERM, Dijon, France | [c] Centre de Lutte Contre le Cancer GF Leclerc, Dijon, France | [d] Service Neurologie, CHU Fattouma Bourguiba, Monastir, Tunisia | [e] Service Neurologie, CHU Sahloul, Sousse, Tunisia | [f] Service Neurologie, CHU de Dijon, Dijon, France
Correspondence:
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Correspondence to: Dr. Gérard Lizard, Laboratoire BIO-peroxIL–EA 7270/INSERM, Faculté des Sciences Gabriel, 6 Bd Gabriel, 21000 Dijon, France. Tel.: +33 380396256; Fax: +33 380396250; E-mail: gerard.lizard@u-bourgogne.fr.
Note: [1] These authors contributed equally to this work.
Abstract: Background:Several lipid metabolism alterations have been described in the brain and plasma of Alzheimer's disease (AD) patients, suggesting a relation between lipid metabolism alteration and dementia. Objective:We attempted to identify blood fatty acids as biomarkers of dementia. Methods:Fatty acid profiles were established using gas chromatography with or without mass spectrometry on matched plasma and red blood cells (RBCs) of demented patients diagnosed with AD, vascular dementia, or other dementia, and compared with a control group of elderly individuals. The severity of dementia was evaluated with the Mini-Mental State Examination test. Results:Fatty acid analysis showed significant variations of fatty acid levels in demented patients including AD patients. The highest plasma and RBC accumulation was found with hexacosanoic acid (C26:0). Our data also support that alterations of desaturase and elongase activities may contribute to cognitive dysfunction. Conclusion:The variations of fatty acid levels and the accumulation of C26:0 in the plasma and RBCs highlight an alteration of fatty acid metabolism in demented patients and point toward possible peroxisomal dysfunction. It is suggested that C26:0 may constitute a convenient blood biomarker of dementia that could be useful in routine medical practice.
