Affiliations: [a] INSERM Center 897 & CIC-1401-EC, Bordeaux University, Bordeaux, France | [b] Bordeaux CHU, CIC-1401-EC Clinical Epidemiology Branch and The Department of Public Health, Bordeaux, France | [c] The Department of Neurology, School of Medicine, at Boston University, Boston, MA, USA | [d] NHLBI's Framingham Heart Study Framingham, MA, USA
Correspondence:
[*]
Correspondence to: Geneviève Chêne, INSERM U897, Université de Bordeaux, ISPED - 146 rue Léo Saignat, 33076 Bordeaux Cédex, France. Tel.: +33 557 571 392; Fax: +33 557 571 172; E-mail: genevieve.chene@isped.u-bordeaux2.fr.
Abstract: There is growing evidence for the importance of cardiovascular risk factors in dementia development, including Alzheimer's disease. As cardiovascular risk profiles vary greatly by gender, with men suffering a greater burden of cardiovascular risk in midlife, this could lead to differences in dementia risk. To explore current evidence on the association between components of the cardiovascular risk profile and dementia risk in women and men, we reviewed all studies reporting the risk of dementia associated with cardiovascular risk factors stratified by gender and found 53 eligible articles out of over 4,000 published since the year 2000. Consistent results were found: 1) for exposures acting specifically in women: Overweight/obesity (harmful) and physical activity (protective), and 2) for exposures acting similarly in women and men: Moderate alcohol (protective) and hypertension, diabetes, and depression (harmful). A modified effect of tobacco or high cholesterol/statin use remained controversial. Available data do not allow us to assess whether selection of men with healthier cardiovascular profile (due to cardiovascular death in midlife) could lead in late life either to a difference in the distribution of risk factors or to a differential effect of these risk factors by gender. We recommend that results on dementia risk factors, especially cardiovascular ones, be reported systematically by gender in all future studies. More generally, as cardiovascular risk profiles evolve over time, more attention needs to be paid to the detection and correction of cardiovascular risk factors, as early as possible in the life course, and as actively in women as in men.
Keywords: Alzheimer's disease, cardiovascular diseases, dementia, prevention, risk factors, women
