Affiliations: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy
Correspondence:
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Correspondence to: Benedetta Nacmias, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. Tel.: +39 0554271379; Fax: +39 0554271380; E-mail: nacmias@unifi.it.
Abstract: Alzheimer's disease (AD) is a multifactorial disorder induced by a combination of genetic and environmental factors, and epigenetic modifications could be the key to understand the pathogenesis of AD. We performed a methylation study of the promoter regions of the three AD principal causative genes in 60 late-onset AD patients and 60 controls. The studied regions in the three causative genes were strongly unmethylated in both groups, but in AD patients the methylation resulted significantly increased. Our study adds new insights to previous ones by showing the involvement of epigenetic changes in AD, which influence the pathogenesis of the disease.
Keywords: Alzheimer's disease, AβPP, DNA methylation, epigenetics, PSEN1, PSEN2
