Cortical Localization of Microbleeds in Cerebral Amyloid Angiopathy: An Ultra High-Field 7T MRI Study

Article type: Research Article

Authors: Ni, Jun^{a; b} | Auriel, Eithan^a | Martinez-Ramirez, Sergi^a | Keil, Boris^c | Reed, Anne K.^a | Fotiadis, Panagiotis^a | Gurol, Edip Mahmut^a | Greenberg, Steven M.^a | Viswanathan, Anand^{a; *}

Affiliations: [a] J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA | [b] The Department of Neurology, Peking Union Medical College Hospital, Peking, China | [c] Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Boston, MA, USA

Correspondence: [*] Correspondence to: Anand Viswanathan, MD, PhD, Harvard Medical School, J. Kistler Stroke Research Center, Massachusetts General Hospital, 175 Cambridge st, Suite 300, Boston, MA 02114, USA. Tel.: +1 617 643 3876; Fax: +1 617 726 5346; E-mail: aviswanathan1@partners.org.

Abstract: The extent of cortical involvement of cerebral amyloid angiopathy (CAA)-related microbleeds (CMBs) remains unclear. We examined five consecutive patients with probable CAA and three non-demented elderly subjects with ultra-high field 7T MRI, to identify the precise location of CAA-related CMBs. In five CAA patients, 169 of a total of 170 lobar CMBs were located in cortical areas on 7T MRI, while a precise cortical versus juxtacortical localization was unable to be determined for 50/76 CMBs observed by conventional MRI. 7T MRI demonstrates that nearly all lobar CMBs are located in cortex in CAA.

Keywords: Cerebral amyloid angiopathy, cerebral microbleed, cortex, magnetic resonance imaging, ultra-high field

DOI: 10.3233/JAD-140864

Journal: Journal of Alzheimer's Disease, vol. 43, no. 4, pp. 1325-1330, 2015