Alzheimer's Disease-Like Pattern of ¹⁸F-FDG Uptake during a Hyperglycemic State and Negative ¹¹C-PiB Binding in a Patient with Mild Cognitive Impairment

Article type: Short Communication

Authors: Ishibashi, Kenji^{a; b; *} | Miura, Yoshiharu^b | Oda, Keiichi^a | Ishiwata, Kiichi^a | Ishii, Kenji^a

Affiliations: [a] Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan | [b] Department of Neurology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan

Correspondence: [*] Correspondence to: Kenji Ishibashi, MD, PhD, Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan. Tel.: +81 3 3964 3241; Fax: +81 3 3964 1148; E-mail: ishibashi@pet.tmig.or.jp.

Abstract: Increased plasma glucose levels can cause the regional reduction of fluorine-18-labeled fluorodeoxyglucose (18F-FDG) uptake in the posterior cingulate, precuneus, and/or temporoparietal cortices as an Alzheimer's disease (AD)-like pattern. However, the association of such an AD-like pattern of cerebral 18F-FDG uptake with AD pathophysiology is unknown. We report a case of a 70-year-old patient with mild cognitive impairment, and show that the AD-like pattern of cerebral 18F-FDG uptake during a hyperglycemic state could be reversible and is not associated with amyloid-β accumulation. Our case concludes that the AD-like pattern is dependent on the plasma glucose level and independent of AD pathophysiology.

Keywords: ¹¹C-PiB, ¹⁸F-FDG, hyperglycemia, PET

DOI: 10.3233/JAD-140639

Journal: Journal of Alzheimer's Disease, vol. 42, no. 2, pp. 385-389, 2014