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Article type: Review Article
Authors: Froestl, Wolfgang; * | Muhs, Andreas | Pfeifer, Andrea
Affiliations: AC Immune SA, EPFL, Lausanne, Switzerland
Correspondence: [*] Correspondence to: Dr. Wolfgang Froestl, AC Immune SA, EPFL, Innovation Park, Building B, CH-1015 Lausanne, Switzerland. Tel.: +0041 21 693 91 43; Fax: +0041 21 693 91 20; E-mail: wolfgang.froestl@acimmune.com.
Abstract: Scientists working in the fields of Alzheimer's disease and, in particular, cognitive enhancers are very productive. The review “Cognitive enhancers (nootropics): drugs interacting with receptors” was accepted for publication in July 2012. Since then, new targets for the potential treatment of Alzheimer's disease were identified. This update describes drugs interacting with 42 receptors versus 32 receptors in the first paper. Some compounds progressed in their development, while many others were discontinued. The present review covers the evolution of research in this field through March 2014.
Keywords: Alzheimer's disease, cognitive enhancers, memantine, memory, nootropics, receptors
DOI: 10.3233/JAD-140228
Journal: Journal of Alzheimer's Disease, vol. 41, no. 4, pp. 961-1019, 2014
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