Hippocampal Neurogenesis in Alzheimer's Disease: Is There a Role for Dietary Modulation?

Article type: Review Article

Authors: Maruszak, Aleksandra | Pilarski, Adam | Murphy, Tytus | Branch, Nicholas | Thuret, Sandrine^{; *}

Affiliations: Department of Neuroscience, Institute of Psychiatry, King's College London, London, United Kingdom

Correspondence: [*] Correspondence to: Dr. Sandrine Thuret, Department of Neuroscience, Institute of Psychiatry, King's College London, 125 Coldharbour Lane, London SE5 9NU, United Kingdom. Tel.: +44 0 20 7848 5405; Fax: +44 0 20 7848 5407; E-mail: sandrine.1.thuret@kcl.ac.uk.

Abstract: Alterations in hippocampal neurogenesis have been recognized as an integral part of Alzheimer's disease. Adult hippocampal neurogenesis is regulated by intrinsic and extrinsic factors; one of them is diet. This review provides an assessment of the current state of the field in hippocampal neurogenesis studies in Alzheimer's disease and focuses on the role of diet. The review highlights some of the key dietary compounds and interventions such as calorie restriction, fat, polyphenols, zinc, folate, alcohol and thiamine, and emphasizes the pathways that they modify.

Keywords: Alzheimer's disease, calorie restriction, diet, fatty acids, folate, neurogenesis, nutrients, polyphenols, thiamine, zinc

DOI: 10.3233/JAD-131004

Journal: Journal of Alzheimer's Disease, vol. 38, no. 1, pp. 11-38, 2014