Clinical Differences in Patients with Alzheimer's Disease According to the Presence or Absence of Anosognosia: Implications for Perceived Quality of Life

Article type: Research Article

Authors: Conde-Sala, Josep L.^{a; *} | Reñé-Ramírez, Ramón^b | Turró-Garriga, Oriol^{c; d} | Gascón-Bayarri, Jordi^b | Juncadella-Puig, Montserrat^b | Moreno-Cordón, Laura^b | Viñas-Diez, Vanesa^b | Garre-Olmo, Josep^{c; e}

Affiliations: [a] Faculty of Psychology, University of Barcelona, Barcelona, Spain | [b] Dementia Unit, Department of Neurology, Bellvitge University Hospital, Hospitalet de Llobregat, Spain | [c] Research Unit, Santa Caterina Hospital, Institut d'Assistència Sanitària, Salt, Spain | [d] Department of Psychiatry and Forensic Medicine, Autonomous University of Barcelona, Bellaterra, Spain | [e] Department of Psychology, University of Girona, Girona, Spain

Correspondence: [*] Correspondence to: Josep Lluís Conde-Sala, University of Barcelona, Passeig Vall d'Hebron, 171, 08035 Barcelona, Spain. Tel.: +34 93 312 5814; Fax: +34 93 402 1368; E-mail: jllconde@ub.edu.

Abstract: This study aimed to determine the factors that predict anosognosia in patients with Alzheimer's disease (AD) and to examine the effect of anosognosia on patient and caregiver perceptions of the patient's quality of life (QoL-p), using a cross-sectional design with 164 patients and their caregivers. Instruments of measurement included Anosognosia Questionnaire-Dementia, Geriatric Depression Scale, Quality of Life in AD (QoL-AD), Disability Assessment for Dementia, Neuropsychiatric Inventory, and the Global Deterioration Scale (GDS). A binary logistic regression analysis was performed to identify the factors that predict anosognosia, while a linear regression analysis was conducted to determine the factors associated with QoL-AD. The degree of anosognosia increased in line with GDS stage (F (2,161) = 41.3, p < 0.001). In the binary regression analysis, the variables that predicted anosognosia were more neuropsychiatric symptoms (OR = 1.11, 95% CI: 1.06–1.17, p < 0.001), deficits in ADL (OR = 0.88, 95% CI: 0.83–0.94, p < 0.001), less depression (OR = 0.66, 95% CI: 0.54–0.82, p < 0.001), and older age (OR = 1.08, 95% CI: 1.00–1.15, p = 0.027). With regards to QoL-p, the multiple linear regression analysis for patients (r2 = 0.486) showed that less depression (β = −0.52, p < 0.001) and greater anosognosia (β = 0.40, p < 0.001) explained 33% and 10% of the variance in QoL-AD, respectively. Greater anosognosia was associated with better perceived QoL-p, especially in advanced GDS stages. Anosognosia was associated with greater caregiver burden and a greater discrepancy between patient and caregiver ratings of QoL-p.

Keywords: Alzheimer's disease, anosognosia, awareness, caregivers, depression, neuropsychiatry, patients, quality of life

DOI: 10.3233/JAD-2012-121360

Journal: Journal of Alzheimer's Disease, vol. 33, no. 4, pp. 1105-1116, 2013