Cerebrovascular Assessment for the Risk Prediction of Alzheimer's Disease

Issue title: Physiopathology of Vascular Risk Factors in Alzheimer's Disease

Guest editors: Jack de la Torre

Article type: Review Article

Authors: Silvestrini, Mauro^{a; *} | Viticchi, Giovanna^a | Altamura, Claudia^b | Luzzi, Simona^a | Balucani, Clotilde^c | Vernieri, Fabrizio^b

Affiliations: [a] Neurological Clinic, Marche Polytechnic University, Ancona, Italy | [b] Neurological Clinic, Campus Bio-Medico University, Roma, Italy | [c] Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA

Correspondence: [*] Correspondence to: Prof. Mauro Silvestrini, Clinica Neurologica, Università Politecnica delle Marche, Via Conca 1, 60020 Ancona, Italy. Tel.: +39 071 596 4532; Fax: +39 071 887 262; E-mail: m.silvestrini@univpm.it.

Abstract: Increasing evidence is emerging that vascular disease and its risk factors play a role in the development of Alzheimer's disease (AD) and affect the probability of an adverse outcome. The aims of this review are to explore the relationship between vascular risk factors and AD and to discuss the potential use of vascular markers in the clinical approach to cognitive impairment. Moreover, we present evidence about the potential use of ultrasonographic and neuroradiologic markers of cognitive impairment in order to establish possible treatment strategies in subjects with a clinical profile at risk of developing AD.

Keywords: Alzheimer's disease, vascular markers, vascular risk factors

DOI: 10.3233/JAD-2012-121240

Journal: Journal of Alzheimer's Disease, vol. 32, no. 3, pp. 689-698, 2012