Very Old Adults with Better Memory Function have Higher Low-Density Lipoprotein Cholesterol Levels and Lower Triglyceride to High-Density Lipoprotein Cholesterol Ratios: KOCOA Project
Affiliations: [a] Department of Neurology, Oregon Health & Science University, Portland, OR, USA | [b] Department of Public Health and Hygiene, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan | [c] Clinical Laboratories, University of the Ryukyus Hospital, Okinawa, Japan | [d] Department of Human Welfare, Okinawa International University, Okinawa, Japan | [e] Department of Cardiovascular Medicine, Nephrology and Neurology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan | [f] Department of Research, Kuakini Medical Center, Honolulu, HI, USA
Correspondence:
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Correspondence to: Yuriko Katsumata, Department of Neurology, Oregon Health & Science University, Mail Code: CR131, 3181 SW Sam Jackson Park Road., Portland, OR 97239-3098, USA. Tel.: +1 503 494 7616; Fax: +1 503 494 7499; E-mail: katsumat@ohsu.edu.
Abstract: We cross-sectionally examined which lipid profiles are associated with better cognitive function among those aged 80 and older, free of dementia (Clinical Dementia Rating ≤0.5), functionally independent, and community-dwelling. Our cohort consisted of 193 participants from the “Keys to Optimal Cognitive Aging (KOCOA) Project”, a prospective cohort study in Okinawa, Japan. Higher low-density lipoprotein cholesterol levels and lower triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratios were associated with higher scores in memory performance after controlling for confounders. Further research is required to clarify the associations among LDL-C levels, TG/HDL-C ratios, and healthy cognitive aging.
Keywords: Aged 80 and over, lipoprotein cholesterol, memory disorders
