Cortical Thinning in Subcortical Vascular Dementia with Negative ¹¹C-PiB PET

Article type: Research Article

Authors: Kim, Chi Hun^a | Seo, Sang Won^{a; *} | Kim, Geon Ha^a | Shin, Ji Soo^a | Cho, Hanna^a | Noh, Young^a | Kim, Suk-Hui^f | Kim, Min Ji^g | Jeon, Seun^c | Yoon, Uicheul^h | Lee, Jong-Min^c | Oh, Seung Jun^e | Kim, Jae Seung^e | Kim, Sung Tae^b | Lee, Jae-Hong^d | Na, Duk L.^{a; *}

Affiliations: [a] Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea | [b] Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea | [c] Department of Biomedical Engineering, Hanyang University, Seoul, South Korea | [d] Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea | [e] Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea | [f] Department of Neurology, Konkuk University Hospital, Konkuk University School of Medicine, Seoul, South Korea | [g] Department of Neurology, University of Florida and Veterans Affairs Medical Center, Gainesville, FL, USA | [h] Department of Biomedical Engineering, Catholic University of Daegu, Daegu, South Korea

Correspondence: [*] Correspondence to: Sang Won Seo, MD, PhD, Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, 135-710 Seoul, Republic of South Korea. Tel.: +82 2 3410 1233; Fax: +82 2 3410 0052; E-mail: sangwonseo@empal.com and Duk L. Na, MD, PhD, Department of Neurology, Sungkyunkwan University, Samsung Medical Center, 50 Ilwon-dong, Kangnam-ku, 135-710 Seoul, South Korea. Tel.: +82 2 3410 3591/3599; Fax: +82 2 3410 0052; E-mail: dukna@skku.edu.

Abstract: To determine the existence of cortical thinning in subcortical vascular dementia (SVaD) with a negative 11C-Pittsburgh compound B (PiB) positron emission tomography scan and to compare the topography of cortical thinning between PiB-negative SVaD and Alzheimer's disease (AD), we enrolled 24 patients with PiB(-) SVaD, 81 clinically probable AD individuals, and 72 normal cognitive controls. Compared with controls, cortical thinning in PiB(-) SVaD was most profound in the perisylvian area, medial prefrontal area, and posterior cingulate gyri, while the precuneus and medial temporal lobes were relatively spared. When the cortical thickness of AD and PiB(-) SVaD were directly compared, PiB(-) SVaD demonstrated significant cortical thinning in the bilateral inferior frontal, superior temporal gyri, and right medial frontal and orbitofrontal lobes, while AD showed significant cortical thinning in the right medial temporal region. SVaD without amyloid burden may lead to substantial cortical atrophy. Moreover, characteristic topography of cortical thinning in PiB(-) SVaD suggests different mechanisms of cortical thinning in PiB(-) SVaD and AD.

Keywords: Alzheimer's disease, cortical thickness, Pittsburgh compound B, subcortical vascular dementia

DOI: 10.3233/JAD-2012-111832

Journal: Journal of Alzheimer's Disease, vol. 31, no. 2, pp. 315-323, 2012