Affiliations: University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
Correspondence:
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Correspondence to: Myron F. Weiner, M.D., 5323 Harry Hines Blvd., Dallas TX 75390 9129, USA. Tel.: +1 214 648 9353; Fax: +1 214 648 2031; E-mail: Myron.weiner@utsouthwestern.edu.
Note: [1] Investigators from the Texas Alzheimer’s Research and Care Consortium: Baylor College of Medicine: Rachelle Doody, Susan Rountree, Violeta Capriles, Christie Ballantyne, Eveleen Darby, Tracy Dawson, Aline Hittle, Aisha Khaleeg; Texas Tech University Health Science Center: Sid O’Bryant, Paula Grammas, Benjamin Williams, Chuang Kuo Wu, Yan Zhang, Gregory Schrimsher, Andrew Dentino, Parastoo Momeni, Larry Hill; University of North Texas Health Science Center: Thomas Fairchild, Janice Knebl, Robert Barber, Douglas Mains, Lisa Alvarez; University of Texas Southwestern Medical Center: Perrie Adams, Roger Rosenberg, Joan Reisch, Ryan Huebinger, Doris Svetlik, Janet Smith Mechelle Murray, Tomequa Sears; University of Texas Health Science Center-San Antonio: Donald Royall, Helen Hazuda, Raymond Palmer, Marsha Polk.
Abstract: To determine if measures of adipokines and other blood lipids differentiate between normal controls and persons with Alzheimer's disease (AD), we examined levels of leptin, adiponectin, total cholesterol, high density lipoproteins (HDL), calculated low density lipoproteins (LDL), triglycerides and apolipoprotein E allele status in 148 early AD subjects and 198 normal controls. We were unable to demonstrate a significant difference in leptin and adiponectin levels between normal controls and AD subjects. We were able to confirm observations of lower HDL and higher total and LDL cholesterol concentration in AD subjects than in controls. As expected, the presence of the apolipoprotein E4 allele distinguished between the two groups.
