Peripheral Antioxidant Markers in Mild Cognitive Impairment and its Progression to Dementia

Article type: Article Commentary

Authors: Panza, Francesco^{a; *} | Solfrizzi, Vincenzo^{b; *} | Seripa, Davide^a | Imbimbo, Bruno P.^c | Pilotto, Alberto^a | Frisardi, Vincenza^b

Affiliations: [a] Geriatric Unit and Gerontology-Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy | [b] Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy | [c] Research & Development Department, Chiesi Farmaceutici, Parma, Italy

Correspondence: [*] Correspondence to: Vincenza Frisardi, MD, Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy. Email: vfrisardi@yahoo.com. Francesco Panza, M.D., Ph.D., Geriatric Unit and Gerontology-Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy. E-mails: geriat.dot@geriatria.uniba.it; f.panza@operapadrepio.it.

Abstract: Mild cognitive impairment (MCI) is recognized as a prodromal phase of dementing disorders, and it has been suggested that oxidative stress may play a role in the pathogenesis of Alzheimer's disease (AD), and in predicting progression of MCI to AD. In the present article, on the basis of an increasing body of evidence from cross-sectional and longitudinal studies, we discussed the issue of the possible impact of antioxidant compounds from diet and supplementation on MCI and its progression to AD.

Keywords: Alzheimer's disease, dementia, mild cognitive impairment, oxidative stress, vascular dementia

DOI: 10.3233/JAD-2010-101224

Journal: Journal of Alzheimer's Disease, vol. 21, no. 4, pp. 1179-1183, 2010