Affiliations: [a] Geriatric Unit and Gerontology-Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy | [b] Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy | [c] Research and Development Department, Chiesi Farmaceutici, Parma, Italy
Correspondence:
[*]
Correspondence to: Vincenza Frisardi, MD, Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy. E-mail: vfrisardi@yahoo.com; Vincenzo Solfrizzi, MD, PhD, Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy. E-mail: v.solfrizzi@geriatria.uniba.it.
Abstract: An increasing body of epidemiological evidence suggested that elevated saturated fatty acids could have negative effects on age-related cognitive decline (ARCD) and mild cognitive impairment (MCI). Furthermore, a clear reduction of risk for cognitive decline has been found in population samples with elevated fish consumption, high intake of monounsaturated fatty acids, and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA. In the present article, on the basis of increasing body of evidence from cross-sectional and longitudinal population-based studies, we discussed the issue of the possible impact of dietary PUFA (both n-6 and n-3) on ARCD, MCI, and Alzheimer's disease.
