Colostrinin™ Alleviates Amyloid-β Induced Toxicity in Rat Primary Hippocampal Cultures

Article type: Short Communication

Authors: Froud, Kristina E. | Wardhaugh, Tina | Banks, Duncan | Saffrey, M. Jill | Stewart, Michael G.^{; *}

Affiliations: Department of Life Sciences, Open University, Walton Hall, Milton Keynes, UK

Correspondence: [*] Correspondence to: Michael G. Stewart, Department of Life Sciences, Open University, Walton Hall, Milton Keynes, MK7 6AA, UK. Tel.: +44 1908 65344; Fax: +44 1908 654167; E-mail: m.g.stewart@open.ac.uk.

Abstract: Colostrinin™ (CLN), a complex mixture of proline-rich polypeptides derived from colostrums, can alleviate cognitive decline in early Alzheimer's disease patients. The molecular basis of the action of CLN has been studied in vitro using human neuroblastoma cell lines. The aim of the present study was to use quantitative immunocytochemistry and immunoblotting to investigate the ability of CLN to relieve amyloid-β (Aβ)-induced cytotoxicity in rat primary hippocampal neuronal cells. Our data confirm that CLN alleviates the effect of Aβ-induced cytotoxicity and causes a significant reduction in the elevated levels of the antioxidant enzyme SOD1.

Keywords: Alzheimer's disease, amyloid-β, colostrinin, hippocampus, oxidative stress, superoxide dismutase

DOI: 10.3233/JAD-2010-1382

Journal: Journal of Alzheimer's Disease, vol. 20, no. 2, pp. 423-426, 2010