Bis (thiosemicarbazonato) Cu-64 Complexes for Positron Emission Tomography Imaging of Alzheimer's Disease

Article type: Research Article

Authors: Fodero-Tavoletti, Michelle T.^{a; b; c} | Villemagne, Victor L.^{a; c; d; *} | Paterson, Brett M.^{b; e} | White, Anthony R.^{a; c; f} | Li, Qiao-Xin^{a; c} | Camakaris, James^g | O'Keefe, Graeme^d | Cappai, Roberto^{a; b} | Barnham, Kevin J.^{a; b; c} | Donnelly, Paul S.^{b; e; *}

Affiliations: [a] Department of Pathology, University of Melbourne, Victoria, Australia | [b] Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria, Australia | [c] The Mental Health Research Institute, Parkville, Melbourne, Victoria, Australia | [d] Department of Nuclear Medicine, Centre for PET, Austin Health, Heidelberg, Victoria, Australia | [e] School of Chemistry, University of Melbourne, Victoria, Australia | [f] Centre for Neuroscience, The University of Melbourne, Victoria, Australia | [g] Department of Genetics, University of Melbourne, Victoria, Australia

Correspondence: [*] Correspondences to: Victor L. Villemagne, Department of Nuclear Medicine, Centre for PET, Austin Health, Studley Road, Heidelberg, Victoria, Australia, 3010. E-mail: villemagne@petnm.unimelb.edu.au. Paul S. Donnelly, School of Chemistry, University of Melbourne, Victoria, Australia, 3010. E-mail: pauld@unimelb.edu.au.

Abstract: A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden.

Keywords: Alzheimer's disease, copper homeostasis, copper radiopharmaceuticals, diagnostic imaging, positron emission tomography (PET)

DOI: 10.3233/JAD-2010-1359

Journal: Journal of Alzheimer's Disease, vol. 20, no. 1, pp. 49-55, 2010