Neuroimaging Through the Course of Alzheimer's Disease

Issue title: Similarities and Differences Between Mild Cognitive Impairment and Alzheimer's Disease

Guest editors: Mark A. Lovell

Article type: Research Article

Authors: Smith, Charles D.^{; *}

Affiliations: Alzheimer's Disease Center, Sanders-Brown Center on Aging, Department of Neurology, Magnetic Resonance Imaging and Spectroscopy Center, Chandler Medical Center, University of Kentucky, Lexington, KY, USA | Sanders-Brown Center on Aging and Alzheimer's Disease Center, Department of Chemistry, University of Kentucky, Lexington, Kentucky, USA

Correspondence: [*] Address for correspondence: Charles D. Smith, MD, Room 62, MRISC (Davis-Mills Building), Chandler Medical Center, 800 Rose Street, Lexington, KY 40536-0098, USA. Tel.: +1 859 323 1113; Fax: +1 859 323 1068; E-mail: csmith@mri.uky.edu.

Abstract: This review uses an image-indexed framework for the full course of Alzheimer's disease (AD) to provide a perspective on recent neuroimaging findings in the literature. Modalities considered include morphometric, diffusion tensor, and functional magnetic resonance imaging, and resting/functional metabolic and amyloid-label positron emission tomography. The major focus is on the AD pre-states (normal but high AD risk and mild cognitive impairment), and transition from mild cognitive impairment to mild AD. Imaging results relevant to the conduct of future prevention and early intervention trials are emphasized.

Keywords: Alzheimer's disease, computed tomography, diffusion tensor imaging, FDG, functional imaging, human, magnetic resonance imaging, mild cognitive impairment, morphometry, PIB, positron emission tomography, prediction, review

DOI: 10.3233/JAD-2010-1217

Journal: Journal of Alzheimer's Disease, vol. 19, no. 1, pp. 273-290, 2010