Implication of GAB2 Gene Polymorphism in Italian Patients with Alzheimer's Disease

Article type: Short Communication

Authors: Nacmias, Benedetta^{a; b; *} | Tedde, Andrea^{a; b} | Bagnoli, Silvia^{a; b} | Cellini, Elena^{a; b} | Guarnieri, Bianca Maria^c | Piacentini, Silvia^{a; b} | Sorbi, Sandro^{a; b}

Affiliations: [a] Department of Neurological and Psychiatric Sciences, University of Florence, Firenze, Italy | [b] Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Firenze, Italy | [c] Casa di Cura “Villa Serena”, Associazione L. Petruzzi, Città Sant Angelo, Pescara, Italy

Correspondence: [*] Corresponding author: Benedetta Nacmias, Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy. Tel.: +39 055 4271379; Fax: +39 055 4271380; E-mail: nacmias@unifi.it.

Note: [] Communicated by Silvia Pellegrini

Abstract: A common polymorphism (rs2373115) in the GRB-associated binding protein 2 (GAB2) gene has been recently associated with the risk of developing Alzheimer's disease (AD) in 644 apolipoprotein E (ApoE) ε4 carriers. In order to assess the involvement of the GAB2 polymorphism in the risk of developing AD, we analyzed the genotype and allele distributions of the GAB2 rs2373115 polymorphism in 579 Italian subjects. Our results support a possible implication of GAB2 genetic variant in AD. However, the observed association was confined to ApoE ε4 non-carriers, thus suggesting a possible role of GAB2 as an independent risk factor for AD.

Keywords: Alzheimer's disease, apolipoprotein E, genetic determinant, GRB-associated binding protein 2

DOI: 10.3233/JAD-2009-1005

Journal: Journal of Alzheimer's Disease, vol. 16, no. 3, pp. 513-515, 2009