From counting neurons to the preclinical diagnosis of Alzheimer's disease

Subtitle: The fruits of collaborative work with Dr. Henryk M. Wisniewski

Article type: Research Article

Authors: Bancher, Christian^{; *}

Affiliations: [a] Ludwig Boltzmann Institute of Clinical Neurobiology, Vienna, Austria | [b] Department of Neurology, Waldviertelklinikum Horn, Austria

Correspondence: [*] Correspondence to: Dr. Christian Bancher, Department of Neurology, Waldviertelklinikum Horn, Spitalgasse 10, A-3580 Horn, Austria. Fax: +43 1 879 8564; E-mail: christian.bancher@univie.ac.at

Abstract: This article is a review of scientific work on Alzheimer neurofibrillary degeneration and Aß-amyloidosis that was done in collaboration with Dr. Henryk Wisniewski, in part at the Institute for Basic Research in Developmental Disabilities. Our work on paired helical filaments and the tau protein spans from basic immunocytochemical analyses of brain tissue to clinical application as a biological marker used in diagnostic tests. Even though only a small part of Dr. Wisniewski's scientific oeuvre, these data illustrate how a great scientist opens the field to his student, collaborator and friend, how basic science can evolve, and how results can be applied in clinical practice to the benefit of our patients.

DOI: 10.3233/JAD-2001-3109

Journal: Journal of Alzheimer's Disease, vol. 3, no. 1, pp. 59-63, 2001