Affiliations: [a] Department of Clinical Chemistry, University and
University Hospital of Liège, Liège, Belgium | [b] Department of Motility Sciences, University and
University Hospital of Liège, Liège, Belgium | [c] CREDEC, Department of Cardiovascular Surgery,
University of Liège, Liège, Belgium
Note: [] Corresponding author: Caroline Le Goff, Department of Clinical
Chemistry, University and University Hospital of Liège, Liège,
Belgium. Tel.: +32 4 366 75 30; E-mail: c.legoff@chu.ulg.ac.be
Abstract: BACKGROUND: Very strenuous exercises can be performed on an
isokinetic dynamometer in order to evaluate the resistance to fatigue of
different muscular groups. Good cardiac function is necessary in order to
perform these very intensive exercises; otherwise an acute myocardial
dysfunction could theoretically appear in predisposed patients. OBJECTIVE: Our study aimed to observe the cardiovascular impact of a
maximal intense isokinetic eccentric exercise performed by a population of
sedentary young men. METHODS: Resting and post-exercise (just after, 3 hours and 24 hours
after the exercise) blood samples were taken from 12 young male sedentary
healthy subjects. These subjects performed an intense maximal eccentric
isokinetic exercise of the quadriceps muscle. We evaluated markers of
cardiovascular risk (troponin I, highly sensitive troponin T, NT-proBNP,
myoglobin), of inflammation (hsCRP) and of oxidative stress (myeloperoxydase,
lipidic peroxides, reduced and oxidised glutathione). RESULTS: The following observations were made: no significant
increase in cardiac (NT-proBNP, troponins) or inflammation (hsCRP) biomarkers;
a significant increase in myoglobin, myeloperoxidase, lipidic peroxides,
oxidised glutathione just after the exercise. CONCLUSIONS: No modification in cardiac biomarkers were observed
after the maximal eccentric isokinetic exercise. We were thus able to prove
that the exercise could be performed without any risk to cardiac function in
young sedentary subjects. However, a significant level of oxidative stress was
induced by this exercise.
