Risk estimation of disorders associated with coeliac disease. A 16-year Danish nationwide follow-up study based on hospital discharge data. Implications for screening
Affiliations: The Danish Epidemiology Science Centre, Aarhus University Hospital, 8000 Aarhus C, Denmark | Department of Internal Medicine V, Aarhus University Hospital, 8000 Aarhus C, Denmark | Department of Internal Medicine M, Aalborg Hospital, 9000 Aalborg, Denmark
Note: [] Correspondence: Henrik Toft Sørensen, The Danish Epidemiology Science Centre, University of Aarhus, Norrebrogade 44, building 2C, DK-8000 Aarhus C, Denmark.
Note: [] The study was supported by the Becket Foundation, the North Jutland Research Foundation, the Foundation of director acob Madsen and his wife Olga Madsen, and the memorial grant of Johs. M. Klein and wife. The activities of The Danish Epidemiology Science Centre are financed by a grant from The Danish National Research Foundation.
Abstract: We studied the association between coeliac disease and other diseases in a cohort of 896 persons who were registered in the Danish National Registry of Patients during a 16-year period. The registry contains information on all discharge diagnoses from Danish somatic hospitals. The total number of observation years in the cohort was 7144 years. The background population was 5.1 million. The strongest association was found with diabetes mellitus, pancreatic diseases and dermatitis herpetiformis. A weaker association was found with small intestinal cancer, malignant haematological disorders, agammaglobulinaemia and rheumatoid arthritis. Conclusively, our population-based study supported the association between coeliac disease and several other chronic diseases, but a weaker association than indicated in other less comprehensive studies and case reports.
