Affiliations: Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia | Department of Philosophy, California State University, Northridge, CA, USA | Discipline of General Practice, University of Adelaide, Adelaide, South Australia
Note: [] Address for correspondence: Jon N. Jureidini, Department of Psychological Medicine, Women's and Children's Hospital, North Adelaide, 5006 Australia. Tel.: +61881617226; E-mail: jon.jureidini@cywhs.sa.gov.au.
Abstract: Selective reporting is prevalent in the medical literature, particularly in industry-sponsored research. In this paper, we expose selective reporting that is not evident without access to internal company documents. The published report of study 329 of paroxetine in adolescents sponsored by GlaxoSmithKline claims that “paroxetine is generally well tolerated and effective for major depression in adolescents”. By contrast, documents obtained during litigation reveal that study 329 was negative for efficacy on all 8 protocol specified outcomes and positive for harm.
Keywords: Selective reporting, SSRI, litigation, industry sponsorship
