Amodiaquine-induced dystonic reactions: Case reports and implications for policy change in Ghana

Article type: Research Article

Authors: Akpalu, Jr., A.K. | Nyame, P.K. | Dodoo, A.N.O.^;

Affiliations: Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana | Centre for Tropical Clinical Pharmacology and Therapeutics, University of Ghana Medical School, Korle-Bu Teaching Hospital, PO Box 4236, Accra, Ghana

Note: [] Corresponding author. Tel./Fax: +233 21 668219; E-mail: alexooo@yahoo.com.

Abstract: Ten cases of amodiaquine-induced dystonic reactions observed in a single ward in Ghana's Premier Teaching Hospital, over a period of 4 years are presented. All the reactions resolved without sequalae on treatment with diazepam and benztropine. The importance of increased safety monitoring of amodiaquine as it is (in combination with artesunate) introduced as first line treatment for uncomplicated malaria in Ghana is highlighted.

Keywords: Amodiaquine, drug-induced dystonic reactions

Journal: International Journal of Risk and Safety in Medicine, vol. 17, no. 1-2, pp. 1-4, 2005