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Article type: Research Article
Authors: Hunfeld, Nicole G.M.; | ten Berge, Rosita L. | LeBrun, Paul P.H.; | Smith, Sierd J. | Melief, Piet H.G.J.
Affiliations: Hospital Pharmacy, Haga Teaching Hospital, The Hague, The Netherlands | Department of Pathology, Haga Teaching Hospital, The Hague, The Netherlands | Department of Internal Medicine, Haga Teaching Hospital, The Hague, The Netherlands | Intensive Care Unit, Haga Teaching Hospital, The Hague, The Netherlands | Central Hospital Pharmacy, The Hague, The Netherlands
Note: [] Address for correspondence: Nicole G.M. Hunfeld, Hospital Pharmacy, Haga Teaching Hospital, Leyweg 275, Den Haag, The Netherlands. E-mail: N.Hunfeld@Hagaziekenhuis.nl
Abstract: This case report describes an episode of acute hepatotoxicity with liver injury after citalopram use in an 83-year old female. Drug intake was stopped immediately on admission. A biopsy of the liver showed extensive liver cell damage and inflammation consistent with drug-induced injury. After cessation of drug intake, the patient fully recovered within a couple of days. Recommencing of medication, with the exception of citalopram, did not cause liver abnormalities during one year of follow-up.
Keywords: Hepatotoxicity, citalopram, case report
DOI: 10.3233/JRS-2010-0486
Journal: International Journal of Risk & Safety in Medicine, vol. 22, no. 1, pp. 1-5, 2010
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