Affiliations: Rotman Research Institute and Institute of Medical Science, University of Toronto, Toronto, Canada | School of Social and Community Medicine, University of Bristol, Bristol, UK | Montreal Neurological Institute, McGill University, Canada | University of Quebec in Chicoutimi, Chicoutimi, Quebec, Canada | ECOBES, Research and transfert, CEGEP Jonquière, Jonquière, Quebec, Canada | Hospital for Sick Children University of Toronto, Toronto, Canada
Note: [] Address for correspondence: Tomáš Paus, Rotman Research Institute, 3560 Bathurst Street, Toronto, Ontario, M6A 2E1, Canada. E-mail: tpaus@research.baycrest.org
Abstract: It is important to account for timing of puberty when studying the adolescent brain and cognition. The use of classical methods for assessing pubertal status may not be feasible in some studies, especially in male adolescents. Using data from a sample of 478 males from a longitudinal birth cohort, we describe the calculations of three independent height-based markers of pubertal timing: Age at Peak Height Velocity (APHV), Height Difference in Standard Deviations (HDSDS), and Percent Achieved of Adult Stature (PAAS). These markers correlate well with each other. In a separate cross-sectional study, we show that the PAAS marker correlates well with testosterone levels and self-reported pubertal-stage scores. We conclude by discussing key considerations for investigators when drawing upon these methods of assessing pubertal timing.
