Affiliations: State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai, China
Correspondence:
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Corresponding author: Wenguang Zhang, State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai 200240, China. Tel.: +86 21 34204851; E-mail:zhwg@sjtu.edu.cn
Abstract: Brain micromotion is one of the key factors that
influence the longevity of neural probes. In order to improve the long-term
stability of brain implanted electrodes, finite element (FE) models,
utilizing hyper-viscoelastic constitutive equations, are developed to
conduct a series of dynamic analysis of the neural probe-brain model. The
influences of neural probe geometry parameters (e.g. tip fillet, wedge
angle, wall thickness) on micromotion induced brain injury are investigated.
The results show that fillet radius of 20 micrometers keeps both the maximum
strain and injury zone in a small region while wedge angle of 70 degree
leads to a 10.34% reduction in strain and 34.52% reduction in injury
zone. Wall thickness of 15 micrometers generates the minimal injury zone and
should be minimized under the condition of probe strength. The results will
provide guidance on the development of novel neural probes with long-term
stability.
Keywords: Micromotion, neural probe, geometry parameter, finite element
